Investigation Healing Effects of Isgın and Dandelion against of Doxorubicin-Induced Toxicity in D. melanogaster

  • Deniz ALTUN ÇOLAK Erzincan Binali Yıldırım University
  • Tuğba ATICI
Keywords: Doxorubicin, Drosophila melanogaster, Rheum ribes, Taraxacum officinale, The survival rate


Chemotherapy is one of the effective methods used in the treatment of cancer. The greatest concern during the use of chemotherapeutic drugs is side effects. Increasing free radical formation in cells and tissues and thus oxidative stress is known as one of the most damaging systems. Antioxidants used during chemotherapy may increase the efficiency of treatment by decreasing the formation of radicals due to oxidative stress and prevent healthy cells from being damaged. From this point of view, the therapeutic and protective properties of Isgın (Rheum ribes) and Dandelion (Taraxacum officinale) giant toxic effects of Doxorubicin, one of the drugs used in chemotherapy, were investigated by conducting survival rate experiments on Drosophila melanogaster. For this purpose, in each experimental set, fly larvae (72±4 hours) were placed in the media and individuals who developed from larvae were recorded. As a result of the study, it was determined that the percentage of survival rate decreased in Doxorubicin treated group compared to the control. In addition, while the percentage of survival rates belonging to Isgın and Dandelion treated groups were higher than the control, the values in plant extracts plus Doxorubicin treated groups were close to the control. These differences in survival percentage were statistically significant (p<0.05). This protective effect can be explained by the inhibition of the formation of free oxygen radicals by the antioxidant properties of plants and the removal of them from the biological system.