ANTIOXIDANT ACTIVITIES AND IN VITRO WOUND HEALING EFFECTS OF META COLLAGEN

Hung-Yuan  Kao; Shu-I  Jen; Yu-Chen  Kao; Zong-Keng Kuo; Szu-Hsiu  Liu

Authors

Hung-Yuan Kao Technical Department, Jellice Pioneer Private Limited Taiwan Branch (Singapore), Pingtung County, Taiwan https://orcid.org/0000-0003-3271-6006
Shu-I Jen Dermatologic Skin Care and Cosmetics Technology, Industrial Technology Research Institute, Hsinchu, Taiwan https://orcid.org/0000-0002-9833-2315
Yu-Chen Kao Dermatologic Skin Care and Cosmetics Technology, Industrial Technology Research Institute, Hsinchu, Taiwan https://orcid.org/0000-0002-1016-0839
Zong-Keng Kuo Dermatologic Skin Care and Cosmetics Technology, Industrial Technology Research Institute, Hsinchu, Taiwan https://orcid.org/0000-0003-1877-2562
Szu-Hsiu Liu Dermatologic Skin Care and Cosmetics Technology, Industrial Technology Research Institute, Hsinchu, Taiwan https://orcid.org/0000-0001-8755-2622

Keywords:

Collagen, antioxidant, wound healing, skin irritation

Abstract

The imbalance of reactive oxygen species (ROS) may cause oxidative stress which is harmful to skin health. Moreover, oxidative stress could also impair the healing of a wound. Antioxidants have been demonstrated their benefits to skin health and wound healing. Previous studies have shown collagen tripeptide has beneficial effects on skins, such as alleviating photoaging, improving skin elasticity and hydration, improving type I collagen synthesis and more. In this study, anti-oxidant activities and in vitro wound healing effects of Meta collagen (Highly content dipeptide and tripeptide) were investigated. The skin irritation test of Meta collagen was also studied. In the DPPH scavenging assay, Meta collagen could scavenge DPPH dose-dependently and showed the anti-oxidant activity. Meta collagen could enhance the migration of NIH-3T3 fibroblasts, suggesting its in vitro wound healing effects. Meanwhile, Meta collagen (1000 mg/mL) is considered as non-irritant to skin by using a reconstructed human epidermis. According to these results, Meta collagen shows anti-oxidant activities and in vitro wound healing effects without skin irritation. Meta collagen might be a potential material to be developed as a skin care product in the future.

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ANTIOXIDANT ACTIVITIES AND IN VITRO WOUND HEALING EFFECTS OF META COLLAGEN

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