SHORT-TERM EFFECTS OF OVARIOHYSTERECTOMY ON SOME ANTIOXIDANT PARAMETERS IN CATSAbstract views: 56 / PDF downloads: 119
Keywords:Cat, ovariohysterectomy, oxidative stress
This research aimed to study the short-term effect of ovariohysterectomy on oxidant/antioxidant status in healthy cats. Twenty-two female cats were allocated to the present study. All the cats were anesthetized with the xylazine-ketamine and spayed. Blood samples were collected before (D0) and three and ten days after the ovariohysterectomy to determine serum malondialdehyde, glutathione, catalase, and glutathione peroxidase concentrations. There was a statistical increase in MDA concentrations on Day 3 compared to Day 0 (p<0.05). There were no statistical differences in the MDA concentrations between Day 3 and Day 10. Catalase activity showed a remarkable increment on Day 3 compared to Day 0 and then a declination on Day 10 compared to Day 3 (p<0.05). Glutathione activity was greater on Day 3 and Day 10 compared to Day 0. Glutathione peroxidase activity was decreased on Day 3 compared to Day 0 and then increased on Day 10. Nevertheless, these increases were not significant. In conclusion, this study clearly showed that ovariohysterectomy surgery resulted in oxidative stress within the first three days after ovariohysterectomy and oxidative stress disappeared ten days after ovariohysterectomy.
Coe, R.J., Grint, N.J., Tivers, M.S., Hotston Moore, A., Holt, P.E. (2006): Comparison of flank and midline approaches to the ovariohysterectomy of cats. Veterinary Record 159(10): 309-313.
Howe, L.M. (2006): Surgical methods of contraception and sterilization. Theriogenology 66(3): 500-509.
Kustritz, M.V.R. (2007): Determining the optimal age for gonadectomy of dogs and cats. Journal of the American Veterinary Medical Association 231(11): 1665-1675.
Brodey, R.S., Roszel, J.F. (1967): Neoplasms of canine uterus vagina and vulva – a clinicopathologic survey of 90 cases. Journal of American Veterinary Medical Association 151: 1294.
Gharagozlou, F., Youssefi, R., Akbarinejad, V., Sasani, F., Taghizadeh-Jahed, M., Shahpoorzadeh, T., Atashbaste, M. (2014): Evaluation of serum anti-Müllerian hormone (AMH) in a Persian queen cat with bilateral cystic ovarian disease. Comparative Clinical Pathology 23: 237-239.
Hagman, R. (2018): Pyometra in small animals. Veterinary Clinics: Small Animal Practice 48(4): 639-661.
Gozer, A., Bahan, O., Dogruer, G., Kutlu, T. (2023): Serum antimüllerian hormone concentrations in female cats. Relation with ovarian remnant syndrome, ovarian cysts and gonadectomy status. Theriogenology 200: 106-113.
Reichler, I.M. (2009): Gonadectomy in cats and dogs: a review of risks and benefits. Reproduction in Domestic Animals 44(2): 29-35.
Taetzsch, S.J., Bertke, A.S., Gruszynski, K.R. (2018): Zoonotic disease transmission associated with feral cats in a metropolitan area: A geospatial analysis. Zoonoses and Public Health 65(4): 412-419.
Bayr, H. (2005): Reactive oxygen species. Critical Care Medicine 33(12): 498-501.
Kucukakin, B., Gogenur, I., Reiter, R.J., Rosenberg, J. (2008): Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?. The Journal of Surgical Research 152: 338–347.
Gutteridge, J.M. (1995): Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clinical Chemistry 41(12): 1819-1828.
Berlett, B.S., Stadtman, E.R. (1997): Protein oxidation in aging, disease, and oxidative stress. Journal of Biological Chemistry 272(33): 20313-20316.
Sies, H. (1997): Oxidative stress: oxidants and antioxidants. Experimental Physiology 82(2): 291–295.
Yoshikawa, T., Naito, Y. (2002). What is oxidative stress?. Japan Medical Association Journal 45(7): 271-276.
Halliwell, B., Matthew, W. (2004): Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?. British Journal of Pharmacology 142(2): 231-255.
Serin, G., Kiral, F., Serin, I. (2008): Acute effect of ovariohysterectomy on lipid peroxidation and some antioxidant levels in dogs. Bulletin of the Veterinary Institute in Pulawy 52: 251-253.
Gunay, A., Gunes, N., Gunay, U. (2011): Effect of Ovariohysterectomy on Lipid Peroxidation and Levels of Some Antioxidants and Biochemical Parameters İn Bitches. Bulletin of the Veterinary Institute in Pulawy 55: 695-698.
Szczubial, M., Kankofer, M., Bochniarz, M., Dąbrowski, R. (2015): Effects of ovariohysterectomy on oxidative stress markers in female dogs. Reproduction in Domestic Animals 50(3): 393-399.
Anadol, E., Yarim, G.F., Gültiken, N., Kazak, F. (2016): Effect of ovariohysterectomy on some oxidative stress markers in the rat. Harran Üniversitesi Veteriner Fakültesi Dergisi 5(2): 124-128.
Sakundech, K., Chompoosan, C., Tuchpramuk, P., Boonsorn, T., Aengwanich, W. (2020): The influence of duration on pain stress, oxidative stress, and total antioxidant power status in female dogs undergoing ovariohysterectomy. Veterinary World 13(1): 160-164
Teixeira, L.G., Martins, L.R., Schimites, P.I., Dornelles, G.L., Aiello, G., Oliveira, J.S., da Silva, F.C., Brum, B.T., Walter, T.M., Andrade, C.M., Soares, A.V. (2020). Evaluation of postoperative pain and toxicological aspects of the use of dipyrone and tramadol in cats. Journal of Feline Medicine and Surgery 22(6): 467-475.
Torabi, A.M., Yasini, S.P., Shirazi, Beheshtiha, S.H. (2022). Evaluation of antioxidant enzymes and lipid peroxidation before and after ovariohysterectomy in queen. Iranian Veterinary Journal 18(1): 71-76.
Placer, Z.A., Cushman, L.L., Johnson, B.C. (1966). Estimation of product of lipid peroxidation (malonyldialdehyde) in biochemical systems. Analytical Biochemistry 16: 359-364.
Goth, L.A. (1991): Simple method for determination of serum catalase activity and revision of reference range. Clinica Chimica Acta 196: 143-152.
Sedlak, J., Lindsay, R.H. (1968): Estimation of total, protein bound and nonprotein sulfhydryl groups in tissue with Ellman’sreagent. Analytical Biochemistry 25: 192-205.
Lawrence, R.A., Burk, R.F. (1976): Glutathione peroxidase activity in selenium-deficient rat liver. Biochemical and Biophysical Research Communications 71(4): 952-958.
Mudron, P., Herzog, K., Höltershinken, M., Rehage, J. (2007): Effects of abdominal surgery on thiobarbituric acid reactive substances and plasma anti-oxidative capacity in dairy cows. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine 54(8): 441-444.
Rosenfeldt, F., Wilson, M., Lee, G., Kure, C., Ou, R., Braun, L., de Haan, J. (2013): Oxidative stress in surgery in an ageing population: pathophysiology and therapy. Experimental Gerontology 48(1): 45-54.
Koźlik, J., Przybyłowska, J., Mikrut, K., Żukiewicz-Sobczak, W.A., Zwoliński, J., Piątek, J., Sobcza, P. (2015): Selected oxidative stress markers in gynecological laparoscopy. Videosurgery and Other Miniinvasive Techniques 10(1): 92-100.
Salavati, S., Mogheiseh, A., Nazifi, S., Amiri, A., Nikahval, B. (2021): The effects of melatonin treatment on oxidative stress induced by ovariohysterectomy in dogs. BMC Veterinary Research 17(1): 1-8.
Haliwell, B., Chirico, S. (1993): Lipid peroxidation: Its mechanism, measurement, and significance. American Journal of Clinical Nutrition 57: 7155-7255.
Yilmaz, O., Korkmaz, M., Jaroszewski, J.J., Yazici, E., Ulutas, E., Saritas, Z.K. (2014): Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches. Polish Journal of Veterinary Sciences 17(3): 493–499.
Anup, R., Aparna, V., Pulimood, A., Balasubramanian, K.A. (1999): Surgical Stress and The Small Intestine: Role of Oxygen Free Radicals. Surgery 125: 560-569.
Kehlet, H., Holte, K. (2001): Effect of postoperative analgesia on surgical outcome. British Journal of Anaesthesia 87(1): 62-72.
Nandi, A., Yan, L.J., Jana, C.K., Das, N. (2019): Role of catalase in oxidative stress-and age-associated degenerative diseases. Oxidative Medicine and Cellular Longevity 2019: 9613090.
Azevedo, R.B., Lacava, Z.G.M., Miyasaka, C.K., Chaves, S.B., Curi, R. (2001). Regulation of antioxidant enzyme activities in male and female rat macrophages by sex steroids. Brazilian Journal of Medical and Biological Research 34: 683-687.
Matés, J.M., Pérez-Gómez, C., De Castro, I.N. (1999): Antioxidant enzymes and human diseases. Clinical Biochemistry 32(8): 595-603.
Franco, A.A., Odom, R.S., Rando, T.A. (1999): Regulation of antioxidant enzyme gene expression in response to oxidative stress and during differentiation of mouse skeletal muscle. Free Radical Biology and Medicine 27(9-10): 1122-1132.
Arora, K.S., Gupta, N., Singh, R.A., Nagpal, S., Arora, D. (2009): Role of free radicals in menopausal distress. Journal of Clinical Diagnosis Research 3: 1900–1902.
Pérez-Torres, I., Guarner-Lans, V., Rubio-Ruiz, M.E. (2017): Reductive stress in inflammation-associated diseases and the pro-oxidant effect of antioxidant agents. International Journal of Molecular Sciences 18(10): 2098.
Li, Y., Wei, G., Chen, J. (2004): Glutathione: a review on biotechnological production. Applied Microbiology and Biotechnology 66(3): 233-242.
Luo, J.L., Hammarqvist, F., Andersson, K., Wernerman, J. (1996): Skeletal muscle glutathione after surgical trauma. Annals of Surgery 223(4): 420.
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