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Histopathology, naftalan, rat, silver, wound healing


The aim of this study is to compare the effects of epidermal growth factor, silver and naftalan on wound healing in rats through clinical and histopathological studies. Four groups each containing 18 rats were formed. Group 1; control group, group 2; epidermal growth factor (EGF) group, group 3; epidermal growth factor (EGF) + silver group, group 4; epidermal growth factor (EGF) + naftalan group. Under anesthesia, a 20 mm long full layer skin resection was performed from dorsal interscapular region. On the 7th, 14th and 21st day postoperatively, wound sizes were measured with millimetric paper for all animals and 6 animals sacrified from each group under deep anesthesia and extensive skin resection of the wound area was performed to sent for histopathological examination. When the wound healing was examined macroscopically between groups, there was no statistical difference in wound diameter measurements on the 7th and 21st postoperative days, while a statistical difference was observed in the EGF + Ag and EGF + Naf groups compared to the sham group in the postoperative 14th day controls (P<0.05). In histopathological examinations, it was determined that neovascularization and epithelialization in the Silver and Naftalan containing group were significantly higher than the sham group in the 7th day samples (p<0.05). In the 14th day samples, inflammation was observed to be statistically higher in the silver and naftalan groups (p<0.05). In the 21st day samples, inflammation was found to be statistically less in the group containing silver and naftalan and bleeding was found to be statistically higher in the group containing silver (P<0.05). Consequently, it was observed that macroscopically and histopathologically, the wound healing was faster in animals treated with EGF + napthalan group compared to other groups.


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How to Cite

Karslı, B., & Kürüm, B. (2024). COMPARISION OF THE EFFICIENCY OF EPIDERMAL GROWTH FACTOR, SILVER AND NAFTALAN IN THE WOUND HEALING OF RATS. Journal of Applied Biological Sciences, 18(1), 106–117. Retrieved from