ANTIOXIDANT EFFECTS OF VIBURNUM OPULUS ON STREPTOZOTOCIN-INDUCED EXPERIMENTAL DIABETIC RATS

Abstract

Streptozotocin is a diabetogenic agent that causes a hyperglycemic situation due to oxidative stress and decreasing the capability of oxygen production properties of β-cells by creating damage on B-cells which produced insulin and located in the pancreas. The aim of this study was to investigate the effects of Viburnum opulus (gilaburu) on the antioxidative metabolism in experimental diabetic rats with streptozotocin. For this purpose, 40 male Wistar albino rats were divided into 4 groups of 10 rats. Following the formation of diabetes, the rats were kept in individual cages and given gilaburu oral gavage at a dose of 100 mg/kg for 15 days. At the end of the study period, MDA, SOD and CAT analyzes were performed by centrifuging the tubes from all groups with EDTA tubes. As a result of analysis, the values of CAT in blood were detected as 62,79±11,42 k/gHb; 32,10±8,81 k/gHb; 38,61±20,62 k/gHb; 21,73±21,40 k/gHb for control, diabetes, gilaburu and diabetes + gilaburu groups respectively, the values of SOD in blood were detected as 127,89±28,78 U/gHb; 168,58±41,84 U/gHb; 157,09±32,71 U/gHb; 125,27±12,13 U/gHb for control, diabetes, gilaburu and diabetes + gilaburu groups respectively, the values of CAT in blood were detected as 1,31±0,28 μmol/L; 1,39±0,59 μmol/L; 1,34±0,14 μmol/L; 1,11±0,10 μmol/L for control, diabetes, gilaburu and diabetes + gilaburu groups respectively. The results of this study support the use of gilaburu, which is widely used in Turkey, among the public, especially in alternative medicine.