INVESTIGATION OF THE CLINICAL EFFICACY OF DIFFERENT FORMS OF ALGAN HEMOSTATIC AGENT (AHA) IN THE RAT ABDOMINAL AORTIC BLEEDING MODEL

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Algan hemostatic agent (AHA), aort, bleeding, rat

Abstract

In cases of death due to trauma, failure to control bleeding is shown as one of the main reasons. Therefore, effective and rapid control of bleeding is very important in reducing traumatic death rates. Many hemostatic products are used for this purpose. Algan Hemostatic Agent (AHA) is a herbal hemostatic agent obtained from a mixture of different plants. The aim of this study was to determine the efficacy of the herbal extract Algan Hemostatic Agent (AHA) in different pharmacological forms in the abdominal aortic injury model of rats. Sixty four 5-8 weeks old male rats were randomly divided into 8 groups, each consisting of eight rats (4 groups were heparinized and 4 groups were non-heparinized). Experimental abdominal aortic hemorrhage was established and physiological saline soaked sponge was applied to the control group. AHA liquid soaked sponge, liquid and powder forms were applied to the experimental groups. Bleeding time was found to be significantly shorter in other AHA groups compared to the control group. The AHA powder form was able to control bleeding by 62.5% and 87.5% in the heparinized and non-heparinized groups, respectively, in the second application (3 minutes). In the second application, the AHA sponge formulation was able to control bleeding at 37.5% and 62.5% in the heparinized and non-heparinized groups, respectively. In the second application, the AHA liquid formulation was able to control the bleeding by 50% and 75% in the heparinized and non-heparinized groups, respectively. After three applications, bleeding was controlled in all AHA groups. Bleeding could not be controlled in the heparinized and non-heparinized control groups and the bleeding time was over 6 minutes. According to the results of this study, it has been shown that AHA is an effective hemostatic agent in bleeding control compared to the control group. Again, this study showed that the technique of creating an injury with a needle in the aortic hemorrhage model is more standardized than other methods.

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Ekici, H., Kumandas, A., Ozbaykus, AC., Dizdaroglu, H., Midi, A., Balik, MS., Yesilada E. (2022): Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. Bezmialem Sci 10(1): 88-96.

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Published

2022-09-28

How to Cite

Kumandas, A., & Ekici, H. (2022). INVESTIGATION OF THE CLINICAL EFFICACY OF DIFFERENT FORMS OF ALGAN HEMOSTATIC AGENT (AHA) IN THE RAT ABDOMINAL AORTIC BLEEDING MODEL. Journal of Applied Biological Sciences, 16(3), 386–395. Retrieved from https://jabsonline.org/index.php/jabs/article/view/1088

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