PHENYLTHIOCARBAMIDE (PTC) TASTE PERCEPTION: A STUDY CORRELATING THE SENSITIVITY TO BITTER TASTE AND THE INFLUENCE OF VARIOUS DEMOGRAPHIC AND PSYCHOGRAPHIC PARAMETERSAbstract views: 188 / PDF downloads: 206
Keywords:Phenylthiocarbamide (PTC), bitterness, tasters, non-tasters, food preferences
The current study sought to elucidate the relationship between taste sensitivity to phenylthiocarbamide (PTC) in a group of 157 people of both sexes (67 males and 90 females), representing a random sample of the population over the age of 18, with diverse food preferences and dietary habits. The taste sensitivity to (PTC), a bitter-tasting compound (determined to be a genetically controlled trait) was carried out with the help of PTC strips. The study also exploited the fact that the various demographic variables such as age, sex, and psychographic parameters like food choices, lifestyle, etc., significantly influenced the taste perception of phenylthiocarbamide and therein other bitter-tasting compounds. The results expressed a clear demarcation (p 0.5) between the taster and non-taster status between both the sexes; with the females being more sensitive to PTC (72.2% as tasters) than the males (64.2 %). A significant rise was observed in the taster status among individuals aged 18–24 years, with 75.49 % as tasters. PTC taster status and beverage consumption frequency were found to be negatively correlated; the opposite was observed for non-tasters. The study also extrapolated the finding that phenylthiocarbamide (PTC) tasters have a higher rejection of strong-tasting foods, whereas non-tasters have a higher acceptance of these foods. PTC can be used as a genetic marker to pinpoint risk factors related to and a reliable determinant of susceptibility to weight gain. Individuals who are sensitive to bitter tastes often have a fairly low orientation for bitter-tasting foods. The key findings of this study indicate a link between PTC perception and variables such as age, gender, food choices, and dietary habits.
Cole, L. A., & Kramer, P. R. (2016): Human Physiology, Biochemistry and Basic Medicine, 1st ed. Academic Press: Elsevier Inc.
Adler, E., Hoon, M. A., Mueller, K. L., Chandrashekar, J., Ryba, N. J., & Zuker, C. S. (2000): A novel family of mammalian taste receptors. Cell 100(6): 693–702. https://doi.org/10.1016/s0092-8674(00)80705-9.
Khataan, N. H., Stewart, L., Brenner, D. M., Cornelis, M. C., & El-Sohemy, A. (2009): TAS2R38 genotypes and phenylthiocarbamide bitter taste perception in a population of young adults. Journal of Nutrigenetics and Nutrigenomics 2(4-5): 251–256. https://doi.org/10.1159/000297217.
Rupesh, S., & Nayak, U. A. (2006): Genetic sensitivity to the bitter taste of 6-n propylthiouracil: a new risk determinant for dental caries in children. Journal of Indian Society of Pedodontics and Preventive Dentistry: 24(2): 63.
Bartoshuk, L. M., Duffy, V. B., & Miller, I. J. (1994): PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiology & Behavior 56(6): 1165-1171.
Tepper B. J. (1998): 6-n-Propylthiouracil: a genetic marker for taste, with implications for food preference and dietary habits. American Journal of Human Genetics 63(5): 1271–1276. https://doi.org/10.1086/302124.
Sharma, K., & Kaur, G. K. (2014): PTC bitter taste genetic polymorphism, food choices, physical growth in body height and body fat related traits among adolescent girls from Kangra Valley, Himachal Pradesh (India). Annals of Human Biology 41(1): 29–39. https://doi.org/10.3109/03014460.2013.822929.
Snedecor, S. M., Pomerleau, C. S., Mehringer, A. M., Ninowski, R., & Pomerleau, O. F. (2006): Differences in smoking-related variables based on phenylthiocarbamide “taster” status. Addictive Behaviors, 31(12): 2309-2312. https://doi.org/10.1016/j.addbeh.2006.02.016.
Risso, D. S., Mezzavilla, M., Pagani, L., Robino, A., Morini, G., Tofanelli, S., Carrai, M., Campa, D., Barale, R., Caradonna, F., Gasparini, P., Luiselli, D., Wooding, S., & Drayna, D. (2016): Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal. Scientific Reports 6: 25506. https://doi.org/10.1038/srep25506.
Guo, S. W., & Reed, D. R. (2001): The genetics of phenylthiocarbamide perception. Annals of Human Biology 28(2): 111–142. https://doi.org/10.1080/03014460151056310.
Hong, J. H., Chung, J. W., Kim, Y. K., Chung, S. C., Lee, S. W., & Kho, H. S. (2005): The relationship between PTC taster status and taste thresholds in young adults. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 99(6): 711–715. https://doi.org/10.1016/j.tripleo.2004.08.004.
Rehman, F., Pervez, A., Awais, M., & Shah MM. (2011): Phenylthiocarbamide tasting and its implications - A preliminary study on human population genetics in the Hazara division of Pakistan. Pakistan Journal of Zoology 43: 811-814.
Fareed, M., Shah, A., Hussain, R., & Afzal, M. (2012): Genetic study of phenylthiocarbamide (PTC) taste perception among six human populations of Jammu and Kashmir (India). Egyptian Journal of Medical Human Genetics 13(2): 161-166. https://doi.org/10.1016/j.ejmhg.2012.01.003.
Hussain, R., Shah, A., & Afzal, M. (2014): Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC) Among Some Muslim Populations of Uttar Pradesh, India. Iranian Journal of Public Health 43(4): 441–452.
Dastan, S. D., Degerli, N., Dastan, T., Yildiz, F., Yildi, Y., Durna, Y. M., & Karan, T. (2015): Phenylthiocarbamide taste perception as a possible genetic association marker for nutritional habits and obesity tendency of people. Pakistan Journal of Pharmaceutical Sciences, 28.
Daştan, S. D., Durna, Y. M., & Daştan, T. (2015): The relationships between phenylthiocarbamide taste perception and smoking, work out habits and susceptibility to depression. Turkish Journal of Agriculture-Food Science and Technology 3(6): 418-424.
Doty, R. L., & De Fonte, T. P. (2016): Relationship of Phenylthiocarbamide (PTC) Taster Status to Olfactory and Gustatory Function in Patients with Chemosensory Disturbances. Chemical Senses 41(8): 685–696. https://doi.org/10.1093/chemse/bjw070.
Rahim, H. M., Majeed, R. K., & Rostam, N. A. (2018): Prevalence, biochemical, and genetic analysis of mutated gene related to bitter taste perception for phenylthiocarbamide in Sulaymaniyah Province, Iraq. Medical Journal of Babylon 15(3): 201.
Smail H. O. (2019): The roles of genes in the bitter taste. AIMS genetics 6(4): 88–97. https://doi.org/10.3934/genet.2019.4.88.
Bustos-Saldaña, R., Alfaro-Rodríguez, M., de la Luz Solís-Ruiz, M., Trujillo-Hernández, B., Pacheco-Carrasco, M., & Vázquez-Jiménez, C. (2009): Disminución de la sensibilidad gustativa en diabéticos tipo 2 con hiperglucemia [Taste sensitivity diminution in hyperglycemic type 2 diabetics patients]. Revista Médica del Instituto Mexicano del Seguro Social 47(5): 483-488.
Wang, R., van Keeken, N. M., Siddiqui, S., Dijksman, L. M., Maudsley, S., Derval, D, & Martin, B. (2014): Higher TNF-α, IGF-1, and leptin levels are found in tasters than non-tasters. Frontiers in Endocrinology 5: 125.
Trius-Soler, M., Bersano-Reyes, P. A., Góngora, C., Lamuela-Raventós, R. M., Nieto, G., & Moreno, J. J. (2022): Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables. Genes & Nutrition 17(1): 1-11.
Harris, H., & Kalmus, H. (1949): The measurement of taste sensitivity to phenylthiourea (P.T.C.). Annals of Eugenics 15: 24-31. https://doi.org/10.1111/j.1469-1809.1949.tb02420.x.
Jeon, S., Kim, Y., Min, S., Song, M., Son, S., & Lee, S. (2021): Taste sensitivity of elderly people is associated with quality of life and inadequate dietary intake. Nutrients, 13(5): 1693. https://doi.org/10.3390/nu1305169.
Martelli, M. E., Jacob, N., Morais, M. A., da-Cunha, D. T., Corona, L. P., Capitani, C. D., & Esteves, A. M. (2020): Taste sensitivity throughout age and the relationship with the sleep quality. Sleep Science, 13(1): 32 https://doi.org/10.5935/1984-0063.20190127.
Beck, T. K., Jensen, S., Bjoern, G. K., & Kidmose, U. (2014): The masking effect of sucrose on perception of bitter compounds in Brassica vegetables. Journal of Sensory Studies 29(3): 190-200. https://doi.org/10.1111/joss.12094.
Ong, J. S., Hwang, L. D., Zhong, V. W., An, J., Gharahkhani, P., Breslin, P. A., & Cornelis, M. C. (2018): Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Scientific Reports 8(1): 1-8. https://doi.org/10.1038/s41598-018-34713-z.
Drewnowski, A., & Gomez-Carneros, C. (2000): Bitter taste, phytonutrients, and the consumer: a review. The American Journal of Clinical Nutrition 72(6): 1424-1435. https://doi.org/10.1093/ajcn/72.6.1424.
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