EVALUATION OF THE ANTI-AGING AND WHITENING EFFICACY OF COLLAGEN TRIPEPTIDE AND CHICKEN PROTEIN HYDROLYSATE
Abstract views: 179 / PDF downloads: 369Keywords:
peptides, skin irritation, anti-aging, whiteningAbstract
Aging is one of the inevitable problems people face, age can cause significant change in skin, both inside and out. As such, ingredients that can delay the aging of skin are highly valued. There are many peptides that have been found to be beneficial to human health, they can reduce the risk of diseases and can be used as anti-aging ingredients. Previous studies have evaluated collagen tripeptide and chicken protein hydrolysate. The studies reported that collagen tripeptide and chicken protein hydrolysate can enhance wound healing and improve physical stamina, respectively. Collagen tripeptide and chicken protein hydrolysate have the potential for applications in a variety of fields. In this study, reconstructed human epidermal were used in vitro skin irritation tests to test anti-aging and whitening effects, and the tests were used to evaluate the safety and efficacy of collagen tripeptide and chicken protein hydrolysate. The results showed that collagen tripeptide and chicken protein hydrolysate were non-irritant. At 20 mg/mL, the collagen type I synthesis of chicken protein hydrolysate and collagen tripeptide were increased to 99.3% and 129.4% and promoted fibroblast proliferation to 62.2% and 22.1%. 4 mg/mL of chicken protein hydrolysate can inhibit melanin production at 29.7% (with α-MSH stimulation). There is the potential for use in cosmetics, and may be a potential candidate for development in anti-aging and whitening.
References
Makrantonaki, E., & Zouboulis, C. C. (2007): Molecular mechanisms of skin aging: state of the art. Annals of the New York Academy of Sciences1119(1), 40-50.
Shin, J. W., Kwon, S. H., Choi, J. Y., Na, J. I., Huh, C. H., Choi, H. R., & Park, K. C. (2019): Molecular mechanisms of dermal aging and antiaging approaches. International Journal of Molecular Sciences 20(9), 2126.
Dams, S. D., De Liefde‐van Beest, M., Nuijs, A. M., Oomens, C. W. J., & Baaijens, F. P. T. (2010): Pulsed heat shocks enhance procollagen type I and procollagen type III expression in human dermal fibroblasts. Skin Research and Technology 16(3), 354-364.
Genovese, L., Corbo, A., & Sibilla, S. (2017): An insight into the changes in skin texture and properties following dietary intervention with a nutricosmeceutical containing a blend of collagen bioactive peptides and antioxidants. Skin Pharmacology and Physiology 30(3), 146-158.
Liu, T., Li, N., Yan, Y. Q., Liu, Y., Xiong, K., Liu, Y., ... & Liu, Z. D. (2020): Recent advances in the anti‐aging effects of phytoestrogens on collagen, water content, and oxidative stress. Phytotherapy Research 34(3), 435-447.
Azmi, N., Hashim, P., Hashim, D. M., Halimoon, N., & Majid, N. M. N. (2014): Anti–elastase, anti–tyrosinase and matrix metalloproteinase–1 inhibitory activity of earthworm extracts as potential new anti–aging agent. Asian Pacific Journal of Tropical Biomedicine 4, S348-S352.
Csiszar, A., Labinskyy, N., Jimenez, R., Pinto, J. T., Ballabh, P., Losonczy, G., ... & Ungvari, Z. (2009): Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mechanisms of Ageing and Development, 130(8), 518-527.
Kim, S. K., & Wijesekara, I. (2010): Development and biological activities of marine-derived bioactive peptides: A review. Journal of Functional Foods 2(1), 1-9.
Genovese, L., Corbo, A., & Sibilla, S. (2017): An insight into the changes in skin texture and properties following dietary intervention with a nutricosmeceutical containing a blend of collagen bioactive peptides and antioxidants. Skin Pharmacology and Physiology30(3), 146-158.
Park, S. H., & Jo, Y. J. (2019): Static hydrothermal processing and fractionation for production of a collagen peptide with anti-oxidative and anti-aging properties. Process Biochemistry 83, 176-182.
Apone, F., Barbulova, A., & Colucci, M. G. (2019): Plant and microalgae derived peptides are advantageously employed as bioactive compounds in cosmetics. Frontiers in Plant Science 10, 756.
Pyun, H. B., Kim, M., Park, J., Sakai, Y., Numata, N., Shin, J. Y., & Hwang, J. K. (2012): Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-exposed hairless mice. Preventive Nutrition and Food Science 17(4), 245-253.
Choi, S. Y., Kim, W. G., Ko, E. J., Lee, Y. H., Kim, B. G., Shin, H. J., ... & Lee, H. J. (2014): Effect of high advanced‐collagen tripeptide on wound healing and skin recovery after fractional photothermolysis treatment. Clinical and Experimental Dermatology39(8), 874-880.
Lau, Y. Q., Dai, F. J., Wu, P. T., Chuah, L., Kao, H. Y., & Chau, C. F. (2019).: Enhancement of physical stamina upon the consumption of chicken Protein hydrolysates with different molecular weight distribution. Taiwanese Journal of Agricultural Chemistry & Food Science 57(5, 6), 252-260.
Wu, P. T., Lau, Y. Q., Dai, F. J., Lin, J. T., Kao, H. Y., & Chau, C. F. (2020): Ability of chicken protein hydrolysate to lower serum cholesterol through its bile acid binding activity. CyTA-Journal of Food 18(1), 493-499.
Irritation, I. V. S. Test No. 439: In Vitro Skin Irritation-Reconstructed Human Epidermis Test Method.
Wen, S. Y., Chen, J. Y., Weng, Y. S., Aneja, R., Chen, C. J., Huang, C. Y., & Kuo, W. W. (2017): Galangin suppresses H2O2‐induced aging in human dermal fibroblasts. Environmental Toxicology 32(12), 2419-2427.
Sohn, S. H., Lee, S. W., Shin, Y. S., Kim, H. D., Yang, S. O., Kim, S. Y., & Kim, Y. O. (2013). The effect of cosmetic on anti-wrinkle of Acer mono sap. Korean Journal of Medicinal Crop Science, 21(4), 262-267.
Kim, C. R., Kim, Y. M., Lee, M. K., Kim, I. H., Choi, Y. H., & Nam, T. J. (2017): Pyropia yezoensis peptide promotes collagen synthesis by activating the TGF-β/Smad signaling pathway in the human dermal fibroblast cell line Hs27. International Journal of Molecular Medicine 39(1), 31-38.
Avila Rodríguez, M. I., Rodriguez Barroso, L. G., & Sánchez, M. L. (2018): Collagen: A review on its sources and potential cosmetic applications. Journal of Cosmetic Dermatology 17(1), 20-26.
Ha, B. G., Park, M. A., Lee, C. M., & Kim, Y. C. (2015): Antioxidant Activity and Anti-wrinkle Effects of Aceriphyllum rossii Leaf Ethanol Extract. Toxicological Research31(4), 363-369.
Dams, S. D., De Liefde‐van Beest, M., Nuijs, A. M., Oomens, C. W. J., & Baaijens, F. P. T. (2010): Pulsed heat shocks enhance procollagen type I and procollagen type III expression in human dermal fibroblasts. Skin Research and Technology 16(3), 354-364.
6999.157693.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Journal of Applied Biological Sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.