EVALUATION OF THE ANTI-AGING AND WHITENING EFFICACY OF COLLAGEN TRIPEPTIDE AND CHICKEN PROTEIN HYDROLYSATE
DOI:
https://doi.org/10.71336/jabs.956Keywords:
peptides, skin irritation, anti-aging, whiteningAbstract
Aging is one of the inevitable problems people face, age can cause significant change in skin, both inside and out. As such, ingredients that can delay the aging of skin are highly valued. There are many peptides that have been found to be beneficial to human health, they can reduce the risk of diseases and can be used as anti-aging ingredients. Previous studies have evaluated collagen tripeptide and chicken protein hydrolysate. The studies reported that collagen tripeptide and chicken protein hydrolysate can enhance wound healing and improve physical stamina, respectively. Collagen tripeptide and chicken protein hydrolysate have the potential for applications in a variety of fields. In this study, reconstructed human epidermal were used in vitro skin irritation tests to test anti-aging and whitening effects, and the tests were used to evaluate the safety and efficacy of collagen tripeptide and chicken protein hydrolysate. The results showed that collagen tripeptide and chicken protein hydrolysate were non-irritant. At 20 mg/mL, the collagen type I synthesis of chicken protein hydrolysate and collagen tripeptide were increased to 99.3% and 129.4% and promoted fibroblast proliferation to 62.2% and 22.1%. 4 mg/mL of chicken protein hydrolysate can inhibit melanin production at 29.7% (with α-MSH stimulation). There is the potential for use in cosmetics, and may be a potential candidate for development in anti-aging and whitening.
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